Hi-Tech Pharmaceuticals Citrus Bergamot a citrus fruit native to southern Italy, has garnered attention for its potential benefits in supporting heart health, managing cholesterol levels, and enhancing metabolic function. Rich in polyphenols and flavonoids, this fruit exhibits antioxidant and lipid-lowering properties.​
 
Cholesterol Management
Research indicates that citrus bergamot may positively influence cholesterol profiles.  Additionally, eight trials reported increases in HDL cholesterol following bergamot intervention. ​
The lipid-lowering effects of citrus bergamot are attributed to several mechanisms:​
 
Inhibition of Cholesterol Synthesis: Compounds like neohesperidin and naringin in bergamot may inhibit HMG-CoA reductase, an enzyme crucial for cholesterol production, functioning similarly to statin medications. ​
 
Enhancement of LDL Receptor Activity: Bergamot polyphenols can increase the expression of LDL receptors in the liver, promoting the clearance of LDL cholesterol from the bloodstream. ​
 
Antioxidant Properties: The flavonoids in bergamot exhibit antioxidant effects, reducing oxidative stress and inflammation, which are linked to cardiovascular diseases. ​
 
Reference
https://pubmed.ncbi.nlm.nih.gov/31057945/
https://www.healthline.com/health/cholesterol/can-bergamot-lower-cholesterol?